Paroxysmal nocturnal hemoglobinuria(PNH) is an uncommon acquired clonal disorder characterized by sensitive populations of erythrocytes, granulocytes, and platelets with increased susceptibility to comlement-mediated lysis. Thrombosis, as
complication
of PNH, are common in the extremities, mesentery, portal system, or the cerebral venous system.
Cerebral thrombosis is a major cause of death in patient with PNH, but only a few cases have been reported. Pregnancy in patient with PNH has been reported to have increased frequency of miscarriage, spontaneous abortion, hemolytic crisis,
worsening of
bone marrow aplasia and deep vein thrombosis.
We report two cases of PNH complicated with cerebral thrombosis or spontaneous abortion. The first case is 21-year-old female who developed cerebral venous thrombosis during clinical follow-up. The second case is 36-year-old female who was
admitted
because of iron deficiency anemia with 5 times repeated spontaneous abortion.
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